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Degradation of endogenous proteins and generation of a null-like phenotype in zebrafish using Trim-Away technology
Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the applicability of this method in model organisms has not been investigated. Here, we show that Trim-Away can degrade proteins in zebrafish embry...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343325/ https://www.ncbi.nlm.nih.gov/pubmed/30674345 http://dx.doi.org/10.1186/s13059-019-1624-4 |