Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) progression and chemotherapy insensitivity have been associated with aberrant PI3K/mTOR/MEK signalling. However, cell death responses activated by inhibitors of these pathways can differ – contextually varying with tumour genetic background. Here, we demonstra...

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Detalles Bibliográficos
Autores principales: Burmi, Rajpal S., Maginn, Elaina N., Gabra, Hani, Stronach, Euan A., Wasan, Harpreet S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343713/
https://www.ncbi.nlm.nih.gov/pubmed/30261145
http://dx.doi.org/10.1080/15384047.2018.1504718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343713/
https://www.ncbi.nlm.nih.gov/pubmed/30261145
http://dx.doi.org/10.1080/15384047.2018.1504718

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