Antigen binding allosterically promotes Fc receptor recognition

A key question in immunology is whether antigen recognition and Fc receptor (FcR) binding are allosterically linked. This question is also relevant for therapeutic antibody design. Antibody Fab and Fc domains are connected by flexible unstructured hinge region. Fc chains have conserved glycosylation...

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Detalles Bibliográficos
Autores principales: Zhao, Jun, Nussinov, Ruth, Ma, Buyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343797/
https://www.ncbi.nlm.nih.gov/pubmed/30212263
http://dx.doi.org/10.1080/19420862.2018.1522178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343797/
https://www.ncbi.nlm.nih.gov/pubmed/30212263
http://dx.doi.org/10.1080/19420862.2018.1522178

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