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Generation by phage display and characterization of drug-target complex-specific antibodies for pharmacokinetic analysis of biotherapeutics

Anti-idiotypic antibodies play an important role in pre-clinical and clinical development of therapeutic antibodies, where they are used for pharmacokinetic studies and for the development of immunogenicity assays. By using an antibody phage display library in combination with guided in vitro select...

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Detalles Bibliográficos
Autores principales: Harth, Stefan, Ten Haaf, Andre, Loew, Christian, Frisch, Christian, Knappik, Achim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343800/
https://www.ncbi.nlm.nih.gov/pubmed/30516449
http://dx.doi.org/10.1080/19420862.2018.1538723