The multi-functionality of N-809, a novel fusion protein encompassing anti-PD-L1 and the IL-15 superagonist fusion complex

Here we describe a novel bifunctional fusion protein, designated N-809. This molecule comprises the IL-15/IL15Rα superagonist complex containing the Fc-domain of IgG1 (N-803, formerly designated as ALT-803) fused to two single chain anti-PD-L1 domains. The fully human IgG1 portion of the N-809 molec...

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Detalles Bibliográficos
Autores principales: Jochems, Caroline, Tritsch, Sarah R., Knudson, Karin M., Gameiro, Sofia R., Rumfield, Claire Smalley, Pellom, Samuel T., Morillon, Y. Maurice, Newman, Robby, Marcus, Warren, Szeto, Christopher, Rabizadeh, Shahrooz, Wong, Hing C., Soon-Shiong, Patrick, Schlom, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343815/
https://www.ncbi.nlm.nih.gov/pubmed/30713787
http://dx.doi.org/10.1080/2162402X.2018.1532764

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343815/
https://www.ncbi.nlm.nih.gov/pubmed/30713787
http://dx.doi.org/10.1080/2162402X.2018.1532764

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