An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z

The classical form of α1-antitrypsin deficiency (ATD) is characterized by intracellular accumulation of the misfolded variant α1-antitrypsin Z (ATZ) and severe liver disease in some of the affected individuals. In this study, we investigated the possibility of discovering novel therapeutic agents th...

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Detalles Bibliográficos
Autores principales: Wang, Yan, Cobanoglu, Murat C., Li, Jie, Hidvegi, Tunda, Hale, Pamela, Ewing, Michael, Chu, Andrew S., Gong, Zhenwei, Muzumdar, Radhika, Pak, Stephen C., Silverman, Gary A., Bahar, Ivet, Perlmutter, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343872/
https://www.ncbi.nlm.nih.gov/pubmed/30673724
http://dx.doi.org/10.1371/journal.pone.0209748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343872/
https://www.ncbi.nlm.nih.gov/pubmed/30673724
http://dx.doi.org/10.1371/journal.pone.0209748

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