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A variant of the Escherichia coli anaerobic transcription factor FNR exhibiting diminished promoter activation function enhances ionizing radiation resistance

We have previously generated four replicate populations of ionizing radiation (IR)-resistant Escherichia coli though directed evolution. Sequencing of isolates from these populations revealed that mutations affecting DNA repair (through DNA double-strand break repair and replication restart), ROS am...

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Detalles Bibliográficos
Autores principales: Bruckbauer, Steven T., Trimarco, Joseph D., Henry, Camille, Wood, Elizabeth A., Battista, John R., Cox, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343905/
https://www.ncbi.nlm.nih.gov/pubmed/30673695
http://dx.doi.org/10.1371/journal.pone.0199482