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Probing the impact of nairovirus genomic diversity on viral ovarian tumor domain protease (vOTU) structure and deubiquitinase activity

Post-translational modification of host and viral proteins by ubiquitin (Ub) and Ub-like proteins, such as interferon stimulated gene product 15 (ISG15), plays a key role in response to infection. Viruses have been increasingly identified that contain proteases possessing deubiquitinase (DUB) and/or...

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Detalles Bibliográficos
Autores principales: Dzimianski, John V., Beldon, Brianna S., Daczkowski, Courtney M., Goodwin, Octavia Y., Scholte, Florine E. M., Bergeron, Éric, Pegan, Scott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343935/
https://www.ncbi.nlm.nih.gov/pubmed/30629698
http://dx.doi.org/10.1371/journal.ppat.1007515