PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells

The PLZF transcription factor is essential for osteogenic differentiation of hMSCs; however, its regulation and molecular function during this process is not fully understood. Here, we revealed that the ZBTB16 locus encoding PLZF, is repressed by Polycomb (PcG) and H3K27me3 in naive hMSCs. At the pr...

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Detalles Bibliográficos
Autores principales: Agrawal Singh, Shuchi, Lerdrup, Mads, Gomes, Ana-Luisa R, van de Werken, Harmen JG, Vilstrup Johansen, Jens, Andersson, Robin, Sandelin, Albin, Helin, Kristian, Hansen, Klaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Chromosomes and Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344081/
https://www.ncbi.nlm.nih.gov/pubmed/30672466
http://dx.doi.org/10.7554/eLife.40364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344081/
https://www.ncbi.nlm.nih.gov/pubmed/30672466
http://dx.doi.org/10.7554/eLife.40364

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