Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition

Dysregulation of the cell cycle characterizes many cancer subtypes, providing a rationale for developing cyclin-dependent kinase (CDK) inhibitors. Potent CDK2 inhibitors might target certain cancers in which CCNE1 is amplified. However, current CDK2 inhibitors also inhibit CDK1, generating a toxicit...

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Detalles Bibliográficos
Autores principales: Wood, Daniel J., Korolchuk, Svitlana, Tatum, Natalie J., Wang, Lan-Zhen, Endicott, Jane A., Noble, Martin E.M., Martin, Mathew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344228/
https://www.ncbi.nlm.nih.gov/pubmed/30472117
http://dx.doi.org/10.1016/j.chembiol.2018.10.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344228/
https://www.ncbi.nlm.nih.gov/pubmed/30472117
http://dx.doi.org/10.1016/j.chembiol.2018.10.015

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