Mechanism of Bidirectional Leading-Strand Synthesis Establishment at Eukaryotic DNA Replication Origins

DNA replication commences at eukaryotic replication origins following assembly and activation of bidirectional CMG helicases. Once activated, CMG unwinds the parental DNA duplex and DNA polymerase α-primase initiates synthesis on both template strands. By utilizing an origin-dependent replication sy...

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Detalles Bibliográficos
Autores principales: Aria, Valentina, Yeeles, Joseph T.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344338/
https://www.ncbi.nlm.nih.gov/pubmed/30451148
http://dx.doi.org/10.1016/j.molcel.2018.10.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344338/
https://www.ncbi.nlm.nih.gov/pubmed/30451148
http://dx.doi.org/10.1016/j.molcel.2018.10.019

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