Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability

Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells. Here, we identify a previously unknown role for cohesin. We find that cohesin is required to repress...

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Detalles Bibliográficos
Autores principales: Meisenberg, Cornelia, Pinder, Sarah I., Hopkins, Suzanna R., Wooller, Sarah K., Benstead-Hume, Graeme, Pearl, Frances M.G., Jeggo, Penny A., Downs, Jessica A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344341/
https://www.ncbi.nlm.nih.gov/pubmed/30554942
http://dx.doi.org/10.1016/j.molcel.2018.11.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344341/
https://www.ncbi.nlm.nih.gov/pubmed/30554942
http://dx.doi.org/10.1016/j.molcel.2018.11.001

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