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Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability
Cohesin subunits are frequently mutated in cancer, but how they function as tumor suppressors is unknown. Cohesin mediates sister chromatid cohesion, but this is not always perturbed in cancer cells. Here, we identify a previously unknown role for cohesin. We find that cohesin is required to repress...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344341/ https://www.ncbi.nlm.nih.gov/pubmed/30554942 http://dx.doi.org/10.1016/j.molcel.2018.11.001 |