Prolonged Exposure to Insulin Inactivates Akt and Erk(1/2) and Increases Pancreatic Islet and INS1E β-Cell Apoptosis

Chronic hyperinsulinemia, in vivo, increases the resistance of peripheral tissues to insulin by desensitizing insulin signaling. Insulin, in a heterologous manner, can also cause IGF-1 resistance. The aim of the current study was to investigate whether insulin-mediated insulin and IGF-1 resistance d...

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Detalles Bibliográficos
Autores principales: Rachdaoui, Nadia, Polo-Parada, Luis, Ismail-Beigi, Faramarz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344346/
https://www.ncbi.nlm.nih.gov/pubmed/30697602
http://dx.doi.org/10.1210/js.2018-00140

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344346/
https://www.ncbi.nlm.nih.gov/pubmed/30697602
http://dx.doi.org/10.1210/js.2018-00140

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