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Prolonged Exposure to Insulin Inactivates Akt and Erk(1/2) and Increases Pancreatic Islet and INS1E β-Cell Apoptosis

Chronic hyperinsulinemia, in vivo, increases the resistance of peripheral tissues to insulin by desensitizing insulin signaling. Insulin, in a heterologous manner, can also cause IGF-1 resistance. The aim of the current study was to investigate whether insulin-mediated insulin and IGF-1 resistance d...

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Detalles Bibliográficos
Autores principales:	Rachdaoui, Nadia, Polo-Parada, Luis, Ismail-Beigi, Faramarz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Endocrine Society 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344346/ https://www.ncbi.nlm.nih.gov/pubmed/30697602 http://dx.doi.org/10.1210/js.2018-00140

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