Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell

How is a water-soluble globular protein able to spontaneously cross a cellular membrane? It is commonly accepted that it undergoes significant structural rearrangements on the lipid-water interface, thus acquiring membrane binding and penetration ability. In this study molecular dynamics (MD) simula...

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Detalles Bibliográficos
Autores principales: Volynsky, Pavel E., Nolde, Dmitry E., Zakharova, Galina S., Palmer, Rex A., Tonevitsky, Alexander G., Efremov, Roman G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344525/
https://www.ncbi.nlm.nih.gov/pubmed/30674891
http://dx.doi.org/10.1038/s41598-018-36310-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344525/
https://www.ncbi.nlm.nih.gov/pubmed/30674891
http://dx.doi.org/10.1038/s41598-018-36310-6

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