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Specific refolding pathway of viscumin A chain in membrane-like medium reveals a possible mechanism of toxin entry into cell
How is a water-soluble globular protein able to spontaneously cross a cellular membrane? It is commonly accepted that it undergoes significant structural rearrangements on the lipid-water interface, thus acquiring membrane binding and penetration ability. In this study molecular dynamics (MD) simula...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344525/ https://www.ncbi.nlm.nih.gov/pubmed/30674891 http://dx.doi.org/10.1038/s41598-018-36310-6 |