Astragaloside IV inhibits glucose-induced epithelial-mesenchymal transition of podocytes through autophagy enhancement via the SIRT–NF-κB p65 axis

Both autophagy and podocyte epithelial-mesenchymal transition (EMT) are critical factors in glomerular diseases that involve proteinuria and fibrosis. Here, we sought to determine whether plant-derived saponin astragaloside IV (AS-IV) was able to reverse renal fibrosis and improve renal function thr...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Xiaolei, Gao, Yanbin, Tian, Nianxiu, Wang, Tao, Shi, Yimin, Xu, Jiayi, Wu, Bingjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344540/
https://www.ncbi.nlm.nih.gov/pubmed/30674969
http://dx.doi.org/10.1038/s41598-018-36911-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344540/
https://www.ncbi.nlm.nih.gov/pubmed/30674969
http://dx.doi.org/10.1038/s41598-018-36911-1

Ejemplares similares