Unique mechanism of target recognition by PfoI restriction endonuclease of the CCGG-family

Restriction endonucleases (REs) of the CCGG-family recognize a set of 4–8 bp target sequences that share a common CCGG or CCNGG core and possess PD…D/ExK nuclease fold. REs that interact with 5 bp sequence 5′-CCNGG flip the central N nucleotides and ‘compress’ the bound DNA to stack the inner base p...

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Detalles Bibliográficos
Autores principales: Tamulaitiene, Giedre, Manakova, Elena, Jovaisaite, Virginija, Tamulaitis, Gintautas, Grazulis, Saulius, Bochtler, Matthias, Siksnys, Virginijus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344858/
https://www.ncbi.nlm.nih.gov/pubmed/30445642
http://dx.doi.org/10.1093/nar/gky1137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344858/
https://www.ncbi.nlm.nih.gov/pubmed/30445642
http://dx.doi.org/10.1093/nar/gky1137

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