ITCH nuclear translocation and H1.2 polyubiquitination negatively regulate the DNA damage response

The downregulation of the DNA damage response (DDR) enables aggressive tumors to achieve uncontrolled proliferation against replication stress, but the mechanisms underlying this process in tumors are relatively complex. Here, we demonstrate a mechanism through which a distinct E3 ubiquitin ligase,...

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Detalles Bibliográficos
Autores principales: Chang, Lufen, Shen, Lei, Zhou, Hu, Gao, Jing, Pan, Hangyi, Zheng, Li, Armstrong, Brian, Peng, Yang, Peng, Guang, Zhou, Binhua P, Rosen, Steven T, Shen, Binghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344871/
https://www.ncbi.nlm.nih.gov/pubmed/30517763
http://dx.doi.org/10.1093/nar/gky1199

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344871/
https://www.ncbi.nlm.nih.gov/pubmed/30517763
http://dx.doi.org/10.1093/nar/gky1199

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