MEHMO syndrome mutation EIF2S3-I259M impairs initiator Met-tRNA(i)(Met) binding to eukaryotic translation initiation factor eIF2

The heterotrimeric eukaryotic translation initiation factor (eIF) 2 plays critical roles in delivering initiator Met-tRNA(i)(Met) to the 40S ribosomal subunit and in selecting the translation initiation site. Genetic analyses of patients with MEHMO syndrome, an X-linked intellectual disability syndr...

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Detalles Bibliográficos
Autores principales: Young-Baird, Sara K, Shin, Byung-Sik, Dever, Thomas E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344876/
https://www.ncbi.nlm.nih.gov/pubmed/30517694
http://dx.doi.org/10.1093/nar/gky1213

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344876/
https://www.ncbi.nlm.nih.gov/pubmed/30517694
http://dx.doi.org/10.1093/nar/gky1213

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