RNF8 mediates NONO degradation following UV-induced DNA damage to properly terminate ATR-CHK1 checkpoint signaling

RNF8 plays a critical role in DNA damage response (DDR) to initiate ubiquitination-dependent signaling. To better characterize the role of RNF8 in UV-induced DDR, we searched for novel substrates of RNF8 and identified NONO as one intriguing substrate. We found that: (i) RNF8 ubiquitinates NONO and...

Descripción completa

Detalles Bibliográficos
Autores principales: Deshar, Rakesh, Yoo, Wonjin, Cho, Eun-Bee, Kim, Sungjoo, Yoon, Jong-Bok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344893/
https://www.ncbi.nlm.nih.gov/pubmed/30445466
http://dx.doi.org/10.1093/nar/gky1166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344893/
https://www.ncbi.nlm.nih.gov/pubmed/30445466
http://dx.doi.org/10.1093/nar/gky1166

Ejemplares similares