Quantitative fluorescence imaging determines the absolute number of locked nucleic acid oligonucleotides needed for suppression of target gene expression

Locked nucleic acid based antisense oligonucleotides (LNA-ASOs) can reach their intracellular RNA targets without delivery modules. Functional cellular uptake involves vesicular accumulation followed by translocation to the cytosol and nucleus. However, it is yet unknown how many LNA-ASO molecules n...

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Detalles Bibliográficos
Autores principales: Buntz, Annette, Killian, Tobias, Schmid, Daniela, Seul, Heike, Brinkmann, Ulrich, Ravn, Jacob, Lindholm, Marie, Knoetgen, Hendrik, Haucke, Volker, Mundigl, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344898/
https://www.ncbi.nlm.nih.gov/pubmed/30462278
http://dx.doi.org/10.1093/nar/gky1158

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344898/
https://www.ncbi.nlm.nih.gov/pubmed/30462278
http://dx.doi.org/10.1093/nar/gky1158

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