Synthetic mRNAs Drive Highly Efficient iPS Cell Differentiation to Dopaminergic Neurons

Proneural transcription factors (TFs) drive highly efficient differentiation of pluripotent stem cells to lineage‐specific neurons. However, current strategies mainly rely on genome‐integrating viruses. Here, we used synthetic mRNAs coding two proneural TFs (Atoh1 and Ngn2) to differentiate induced...

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Detalles Bibliográficos
Autores principales: Xue, Yingchao, Zhan, Xiping, Sun, Shisheng, Karuppagounder, Senthilkumar S., Xia, Shuli, Dawson, Valina L., Dawson, Ted M., Laterra, John, Zhang, Jianmin, Ying, Mingyao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Pluripotent Stem Cells
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344911/
https://www.ncbi.nlm.nih.gov/pubmed/30387318
http://dx.doi.org/10.1002/sctm.18-0036

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344911/
https://www.ncbi.nlm.nih.gov/pubmed/30387318
http://dx.doi.org/10.1002/sctm.18-0036

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