Enantioselective synthesis of gem-disubstituted N-Boc diazaheterocycles via decarboxylative asymmetric allylic alkylation

An enantioselective synthesis of diverse N4-Boc-protected α,α-disubstituted piperazin-2-ones using the palladium-catalyzed decarboxylative allylic alkylation reaction has been achieved. Using a chiral Pd-catalyst derived from an electron deficient PHOX ligand, chiral piperazinones are synthesized in...

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Detalles Bibliográficos
Autores principales: Sun, Alexander W., Hess, Stephan N., Stoltz, Brian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345351/
https://www.ncbi.nlm.nih.gov/pubmed/30774872
http://dx.doi.org/10.1039/c8sc03967d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345351/
https://www.ncbi.nlm.nih.gov/pubmed/30774872
http://dx.doi.org/10.1039/c8sc03967d

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