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Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

Microtubule-targeting agents (MTAs) are widely used chemotherapy drugs capable of disrupting microtubule-dependent cellular functions, such as division and migration. We show that two clinically approved MTAs, paclitaxel and vinblastine, each suppress stiffness-sensitive migration and polarization c...

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Detalles Bibliográficos
Autores principales: Prahl, Louis S., Bangasser, Patrick F., Stopfer, Lauren E., Hemmat, Mahya, White, Forest M., Rosenfeld, Steven S., Odde, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345402/
https://www.ncbi.nlm.nih.gov/pubmed/30485822
http://dx.doi.org/10.1016/j.celrep.2018.10.101