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Cis-activation in the Notch signaling pathway

The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling. Here, by analyzing Notch activation in single cells whi...

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Detalles Bibliográficos
Autores principales: Nandagopal, Nagarajan, Santat, Leah A, Elowitz, Michael B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345567/
https://www.ncbi.nlm.nih.gov/pubmed/30628888
http://dx.doi.org/10.7554/eLife.37880