Allosteric Feedback Inhibition Enables Robust Amino Acid Biosynthesis in E. coli by Enforcing Enzyme Overabundance

Microbes must ensure robust amino acid metabolism in the face of external and internal perturbations. This robustness is thought to emerge from regulatory interactions in metabolic and genetic networks. Here, we explored the consequences of removing allosteric feedback inhibition in seven amino acid...

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Detalles Bibliográficos
Autores principales: Sander, Timur, Farke, Niklas, Diehl, Christoph, Kuntz, Michelle, Glatter, Timo, Link, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345581/
https://www.ncbi.nlm.nih.gov/pubmed/30638812
http://dx.doi.org/10.1016/j.cels.2018.12.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345581/
https://www.ncbi.nlm.nih.gov/pubmed/30638812
http://dx.doi.org/10.1016/j.cels.2018.12.005

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