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Elephant APOBEC3A cytidine deaminase induces massive double-stranded DNA breaks and apoptosis

The incidence of developing cancer should increase with the body mass, yet is not the case, a conundrum referred to as Peto’s paradox. Elephants have a lower incidence of cancer suggesting that these animals have probably evolved different ways to protect themselves against the disease. The paradox...

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Detalles Bibliográficos
Autores principales: Li, Xiongxiong, Caval, Vincent, Wain-Hobson, Simon, Vartanian, Jean-Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345769/
https://www.ncbi.nlm.nih.gov/pubmed/30679716
http://dx.doi.org/10.1038/s41598-018-37305-z