Kinetic and thermodynamic effects of phosphorylation on p53 binding to MDM2

p53 is frequently mutated in human cancers. Its levels are tightly regulated by the E3 ubiquitin ligase MDM2. The complex between MDM2 and p53 is largely formed by the interaction between the N-terminal domain of MDM2 and the N-terminal transactivation (TA) domain of p53 (residues 15–29). We investi...

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Detalles Bibliográficos
Autores principales: Yadahalli, Shilpa, Neira, José L., Johnson, Christopher M., Tan, Yaw Sing, Rowling, Pamela J. E., Chattopadhyay, Anasuya, Verma, Chandra S., Itzhaki, Laura S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345774/
https://www.ncbi.nlm.nih.gov/pubmed/30679555
http://dx.doi.org/10.1038/s41598-018-36589-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345774/
https://www.ncbi.nlm.nih.gov/pubmed/30679555
http://dx.doi.org/10.1038/s41598-018-36589-5

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