LC3/GABARAPs drive ubiquitin-independent recruitment of Optineurin and NDP52 to amplify mitophagy

Current models of selective autophagy dictate that autophagy receptors, including Optineurin and NDP52, link cargo to autophagosomal membranes. This is thought to occur via autophagy receptor binding to Atg8 homologs (LC3/GABARAPs) through an LC3 interacting region (LIR). The LIR motif within autoph...

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Detalles Bibliográficos
Autores principales: Padman, Benjamin Scott, Nguyen, Thanh Ngoc, Uoselis, Louise, Skulsuppaisarn, Marvin, Nguyen, Lan K., Lazarou, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345886/
https://www.ncbi.nlm.nih.gov/pubmed/30679426
http://dx.doi.org/10.1038/s41467-019-08335-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345886/
https://www.ncbi.nlm.nih.gov/pubmed/30679426
http://dx.doi.org/10.1038/s41467-019-08335-6

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