5-Fluorouracil Induces Enteric Neuron Death and Glial Activation During Intestinal Mucositis via a S100B-RAGE-NFκB-Dependent Pathway

5-Fluorouracil (5-FU) is an anticancer agent whose main side effects include intestinal mucositis associated with intestinal motility alterations maybe due to an effect on the enteric nervous system (ENS), but the underlying mechanism remains unclear. In this report, we used an animal model to inves...

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Detalles Bibliográficos
Autores principales: Costa, Deiziane V. S., Bon-Frauches, Ana C., Silva, Angeline M. H. P., Lima-Júnior, Roberto C. P., Martins, Conceição S., Leitão, Renata F. C., Freitas, Gutierrez B., Castelucci, Patricia, Bolick, David T., Guerrant, Richard L., Warren, Cirle A., Moura-Neto, Vivaldo, Brito, Gerly A. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345953/
https://www.ncbi.nlm.nih.gov/pubmed/30679569
http://dx.doi.org/10.1038/s41598-018-36878-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345953/
https://www.ncbi.nlm.nih.gov/pubmed/30679569
http://dx.doi.org/10.1038/s41598-018-36878-z

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