Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

New strategies are needed to counter the escalating threat posed by drug-resistant fungi. The molecular chaperone Hsp90 affords a promising target because it supports survival, virulence and drug-resistance across diverse pathogens. Inhibitors of human Hsp90 under development as anticancer therapeut...

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Detalles Bibliográficos
Autores principales: Whitesell, Luke, Robbins, Nicole, Huang, David S., McLellan, Catherine A., Shekhar-Guturja, Tanvi, LeBlanc, Emmanuelle V., Nation, Catherine S., Hui, Raymond, Hutchinson, Ashley, Collins, Cathy, Chatterjee, Sharanya, Trilles, Richard, Xie, Jinglin L., Krysan, Damian J., Lindquist, Susan, Porco, John A., Tatu, Utpal, Brown, Lauren E., Pizarro, Juan, Cowen, Leah E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345968/
https://www.ncbi.nlm.nih.gov/pubmed/30679438
http://dx.doi.org/10.1038/s41467-018-08248-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345968/
https://www.ncbi.nlm.nih.gov/pubmed/30679438
http://dx.doi.org/10.1038/s41467-018-08248-w

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