Acetaldehyde forms covalent GG intrastrand crosslinks in DNA

Carcinogens often generate mutable DNA lesions that contribute to cancer and aging. However, the chemical structure of tumorigenic DNA lesions formed by acetaldehyde remains unknown, although it has long been considered an environmental mutagen in alcohol, tobacco, and food. Here, we identify an ald...

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Detalles Bibliográficos
Autores principales: Sonohara, Yuina, Yamamoto, Junpei, Tohashi, Kosuke, Takatsuka, Reine, Matsuda, Tomonari, Iwai, Shigenori, Kuraoka, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345987/
https://www.ncbi.nlm.nih.gov/pubmed/30679737
http://dx.doi.org/10.1038/s41598-018-37239-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345987/
https://www.ncbi.nlm.nih.gov/pubmed/30679737
http://dx.doi.org/10.1038/s41598-018-37239-6

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