Initiation of Pulmonary Fibrosis after Silica Inhalation in Rats is linked with Dysfunctional Shelterin Complex and DNA Damage Response

Occupational exposure to silica has been observed to cause pulmonary fibrosis and lung cancer through complex mechanisms. Telomeres, the nucleoprotein structures with repetitive (TTAGGG) sequences at the end of chromosomes, are a molecular “clock of life”, and alterations are associated with chronic...

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Detalles Bibliográficos
Autores principales: Shoeb, Mohammad, Mustafa, Gul M., Joseph, Pius, Umbright, Christina, Kodali, Vamsi, Roach, Katherine A., Meighan, Terence, Roberts, Jenny R., Erdely, Aaron, Antonini, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346028/
https://www.ncbi.nlm.nih.gov/pubmed/30679488
http://dx.doi.org/10.1038/s41598-018-36712-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346028/
https://www.ncbi.nlm.nih.gov/pubmed/30679488
http://dx.doi.org/10.1038/s41598-018-36712-6

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