Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice

Sporadic Alzheimer’s disease (AD) is the most common cause of dementia. However, representative experimental models of AD have remained difficult to produce because of the disease’s uncertain origin. The Polycomb group protein BMI1 regulates chromatin compaction and gene silencing. BMI1 expression i...

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Detalles Bibliográficos
Autores principales: El Hajjar, Jida, Chatoo, Wassim, Hanna, Roy, Nkanza, Patrick, Tétreault, Nicolas, Tse, Yiu Chung, Wong, Tak Pan, Abdouh, Mohamed, Bernier, Gilbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346086/
https://www.ncbi.nlm.nih.gov/pubmed/30679733
http://dx.doi.org/10.1038/s41598-018-37444-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346086/
https://www.ncbi.nlm.nih.gov/pubmed/30679733
http://dx.doi.org/10.1038/s41598-018-37444-3

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