Tissue acidosis does not mediate the hypoxia selectivity of [(64)Cu][Cu(ATSM)] in the isolated perfused rat heart

Copper-64-Diacetyl-bis(N(4)-methylthiosemicarbazone) [(64)Cu][Cu(ATSM)] is a hypoxia-targeting PET tracer with applications in oncology and cardiology. Upon entering a hypoxic cell, [(64)Cu][Cu(II)(ATSM)] is reduced to a putative [(64)Cu][Cu(I)(ATSM)](−) species which dissociates to deposit radiocop...

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Detalles Bibliográficos
Autores principales: Baark, Friedrich, Shaughnessy, Fiona, Pell, Victoria R., Clark, James E., Eykyn, Thomas R., Blower, Philip, Southworth, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346098/
https://www.ncbi.nlm.nih.gov/pubmed/30679497
http://dx.doi.org/10.1038/s41598-018-36145-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346098/
https://www.ncbi.nlm.nih.gov/pubmed/30679497
http://dx.doi.org/10.1038/s41598-018-36145-1

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