HPLC analysis of CSF hypocretin-1 in type 1 and 2 narcolepsy

Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin (hcrt) neurons in the hypothalamus. Cerebrospinal fluid (CSF) hcrt-1 measurement has been well established as a gold standard of narcolepsy diagnosis, although some portions of narcoleptic patients show normal hcrt-1 levels. We ai...

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Detalles Bibliográficos
Autores principales: Sakai, Noriaki, Matsumura, Mari, Lin, Ling, Mignot, Emmanuel, Nishino, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346108/
https://www.ncbi.nlm.nih.gov/pubmed/30679597
http://dx.doi.org/10.1038/s41598-018-36942-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346108/
https://www.ncbi.nlm.nih.gov/pubmed/30679597
http://dx.doi.org/10.1038/s41598-018-36942-8

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