Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-...

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Detalles Bibliográficos
Autores principales: Schwertz, Geoffrey, Zanetti, Andrea, Nascimento de Oliveira, Marllon, Gomez Fernandez, Mario Andrès, Dioury, Fabienne, Cossy, Janine, Amara, Zacharias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346372/
https://www.ncbi.nlm.nih.gov/pubmed/30739959
http://dx.doi.org/10.1016/j.tet.2018.12.050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346372/
https://www.ncbi.nlm.nih.gov/pubmed/30739959
http://dx.doi.org/10.1016/j.tet.2018.12.050

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