Synthesis of amorpha-4,11-diene from dihydroartemisinic acid

Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-...

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Autores principales: Schwertz, Geoffrey, Zanetti, Andrea, Nascimento de Oliveira, Marllon, Gomez Fernandez, Mario Andrès, Dioury, Fabienne, Cossy, Janine, Amara, Zacharias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pergamon Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346372/
https://www.ncbi.nlm.nih.gov/pubmed/30739959
http://dx.doi.org/10.1016/j.tet.2018.12.050
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author Schwertz, Geoffrey
Zanetti, Andrea
Nascimento de Oliveira, Marllon
Gomez Fernandez, Mario Andrès
Dioury, Fabienne
Cossy, Janine
Amara, Zacharias
author_facet Schwertz, Geoffrey
Zanetti, Andrea
Nascimento de Oliveira, Marllon
Gomez Fernandez, Mario Andrès
Dioury, Fabienne
Cossy, Janine
Amara, Zacharias
author_sort Schwertz, Geoffrey
collection PubMed
description Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography.
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spelling pubmed-63463722019-02-08 Synthesis of amorpha-4,11-diene from dihydroartemisinic acid Schwertz, Geoffrey Zanetti, Andrea Nascimento de Oliveira, Marllon Gomez Fernandez, Mario Andrès Dioury, Fabienne Cossy, Janine Amara, Zacharias Tetrahedron Article Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-gram scale in four steps with only one chromatography. Pergamon Press 2019-02-08 /pmc/articles/PMC6346372/ /pubmed/30739959 http://dx.doi.org/10.1016/j.tet.2018.12.050 Text en © 2018 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schwertz, Geoffrey
Zanetti, Andrea
Nascimento de Oliveira, Marllon
Gomez Fernandez, Mario Andrès
Dioury, Fabienne
Cossy, Janine
Amara, Zacharias
Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
title Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
title_full Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
title_fullStr Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
title_full_unstemmed Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
title_short Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
title_sort synthesis of amorpha-4,11-diene from dihydroartemisinic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346372/
https://www.ncbi.nlm.nih.gov/pubmed/30739959
http://dx.doi.org/10.1016/j.tet.2018.12.050
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