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Current perspectives on mechanisms of ribonucleotide incorporation and processing in mammalian DNA

Ribonucleotides, which are RNA precursors, are often incorporated into DNA during replication. Although embedded ribonucleotides in the genome are efficiently removed by canonical ribonucleotide excision repair (RER), inactivation of RER causes genomic ribonucleotide accumulation, leading to various...

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Detalles Bibliográficos
Autores principales: Sassa, Akira, Yasui, Manabu, Honma, Masamitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346524/
https://www.ncbi.nlm.nih.gov/pubmed/30700998
http://dx.doi.org/10.1186/s41021-019-0118-7