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Genomic clustering of fitness‐affecting mutations favors the evolution of chromosomal instability
Most solid cancers are characterized by chromosomal instability (CIN)—an elevated rate of large‐scale chromosomal aberrations and ploidy changes. Chromosomal instability may arise through mutations in a range of genomic integrity loci and is commonly associated with fast disease progression, poor pr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346662/ https://www.ncbi.nlm.nih.gov/pubmed/30697341 http://dx.doi.org/10.1111/eva.12717 |