Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks

Insertions of mobile elements(1-4), mitochondrial DNA(5) and fragments of nuclear chromosomes(6) at DNA double strand breaks (DSBs) threaten genome integrity and are common in cancer(7-9). Insertions of chromosome fragments at V(D)J loci can stimulate antibody diversification(10). The origin of inse...

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Detalles Bibliográficos
Autores principales: Yu, Yang, Pham, Nhung, Xia, Bo, Papusha, Alma, Wang, Guangyu, Yan, Zhenxin, Peng, Guang, Chen, Kaifu, Ira, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346745/
https://www.ncbi.nlm.nih.gov/pubmed/30518856
http://dx.doi.org/10.1038/s41586-018-0769-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346745/
https://www.ncbi.nlm.nih.gov/pubmed/30518856
http://dx.doi.org/10.1038/s41586-018-0769-8

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