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Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks
Insertions of mobile elements(1-4), mitochondrial DNA(5) and fragments of nuclear chromosomes(6) at DNA double strand breaks (DSBs) threaten genome integrity and are common in cancer(7-9). Insertions of chromosome fragments at V(D)J loci can stimulate antibody diversification(10). The origin of inse...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346745/ https://www.ncbi.nlm.nih.gov/pubmed/30518856 http://dx.doi.org/10.1038/s41586-018-0769-8 |