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Iba-1(-)/CD68(+) microglia are a prominent feature of age-associated deep subcortical white matter lesions
Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are associated with demyelination, blood brain barrier (BBB) dysfunction, and microgliosis. Microglia are the main immune cell of the brain. Under phys...
Autores principales: | Waller, Rachel, Baxter, Lynne, Fillingham, Daniel J., Coelho, Santiago, Pozo, Jose M., Mozumder, Meghdoot, Frangi, Alejandro F., Ince, Paul G., Simpson, Julie E., Highley, J. Robin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347230/ https://www.ncbi.nlm.nih.gov/pubmed/30682074 http://dx.doi.org/10.1371/journal.pone.0210888 |
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