Blockade of the PD-1 axis alone is not sufficient to activate HIV-1 virion production from CD4(+) T cells of individuals on suppressive ART

Blockade of the programmed cell death protein/ligand 1 (PD-1/PD-L1) pathway with monoclonal antibodies (mAb) is now commonly used for cancer immunotherapy and has therapeutic potential in chronic viral infections including HIV-1. PD-1/PD-L1 blockade could augment HIV-1-specific immune responses and...

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Detalles Bibliográficos
Autores principales: Bui, John K., Cyktor, Joshua C., Fyne, Elizabeth, Campellone, Shalyn, Mason, Stephen W., Mellors, John W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347234/
https://www.ncbi.nlm.nih.gov/pubmed/30682108
http://dx.doi.org/10.1371/journal.pone.0211112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347234/
https://www.ncbi.nlm.nih.gov/pubmed/30682108
http://dx.doi.org/10.1371/journal.pone.0211112

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