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An algorithm for computing profile likelihood based pointwise confidence intervals for nonlinear dose-response models
This study was inspired by the need to estimate pointwise confidence intervals (CIs) for a nonlinear dose-response model from a dose-finding clinical trial. Profile likelihood based CI for a nonlinear dose response model is often recommended. However, it is still not commonly used in dose-finding st...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347253/ https://www.ncbi.nlm.nih.gov/pubmed/30682081 http://dx.doi.org/10.1371/journal.pone.0210953 |