Biased efficacy estimates in phase-III dengue vaccine trials due to heterogeneous exposure and differential detectability of primary infections across trial arms

Vaccine efficacy (VE) estimates are crucial for assessing the suitability of dengue vaccine candidates for public health implementation, but efficacy trials are subject to a known bias to estimate VE toward the null if heterogeneous exposure is not accounted for in the analysis of trial data. In lig...

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Detalles Bibliográficos
Autores principales: España, Guido, Hogea, Cosmina, Guignard, Adrienne, ten Bosch, Quirine A., Morrison, Amy C., Smith, David L., Scott, Thomas W., Schmidt, Alexander, Perkins, T. Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347271/
https://www.ncbi.nlm.nih.gov/pubmed/30682037
http://dx.doi.org/10.1371/journal.pone.0210041

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347271/
https://www.ncbi.nlm.nih.gov/pubmed/30682037
http://dx.doi.org/10.1371/journal.pone.0210041

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