Utilization of proliferable extracellular amastigotes for transient gene expression, drug sensitivity assay, and CRISPR/Cas9-mediated gene knockout in Trypanosoma cruzi

Trypanosoma cruzi has three distinct life cycle stages; epimastigote, trypomastigote, and amastigote. Amastigote is the replication stage in host mammalian cells, hence this stage of parasite has clinical significance in drug development research. Presence of extracellular amastigotes (EA) and their...

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Detalles Bibliográficos
Autores principales: Takagi, Yuko, Akutsu, Yukie, Doi, Motomichi, Furukawa, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347291/
https://www.ncbi.nlm.nih.gov/pubmed/30640901
http://dx.doi.org/10.1371/journal.pntd.0007088

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347291/
https://www.ncbi.nlm.nih.gov/pubmed/30640901
http://dx.doi.org/10.1371/journal.pntd.0007088

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