Quadruplex-forming oligonucleotide targeted to the VEGF promoter inhibits growth of non-small cell lung cancer cells

BACKGROUND: Vascular endothelial growth factor (VEGF) is commonly overexpressed in a variety of tumor types including lung cancer. As a key regulator of angiogenesis, it promotes tumor survival, growth, and metastasis through the activation of the downstream protein kinase B (AKT) and extracellular...

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Detalles Bibliográficos
Autores principales: Muench, David, Rezzoug, Francine, Thomas, Shelia D., Xiao, Jingjing, Islam, Ashraful, Miller, Donald M., Sedoris, Kara C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347295/
https://www.ncbi.nlm.nih.gov/pubmed/30682194
http://dx.doi.org/10.1371/journal.pone.0211046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347295/
https://www.ncbi.nlm.nih.gov/pubmed/30682194
http://dx.doi.org/10.1371/journal.pone.0211046

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